Global defense stocks jumped on Monday as investors reacted to a dramatic military escalation in the Middle East over the weekend.

The sector was a rare bright spot amid a broader market sell-off triggered by fears of a wider regional conflict.

Germany’s Hensoldt and Britain’s BAE Systems were among the top performers in the Stoxx 600, both up around 4%. Defense names Thales, Renk, and Leonardo rose between 4% and 1%, paring earlier gains, while the broader Stoxx 600 index fell more than 1%, touching a two-week low.

Stateside, U.S. firms Lockheed Martin and Northrop Grumman each rose more than 5% in premarket trading. Futures tracking the S&P 500 were down 1.1%.

With South Korean markets closed Monday, regional activity in Asia-Pacific defense sector was somewhat muted. Japan’s defense heavyweights Mitsubishi Heavy Industries and IHI rose about 3% each, while Singapore’s ST Engineering climbed 2.8%.

The moves come after the U.S. and Israel launched widespread attacks on Iran over the weekend that killed Iranian Supreme Leader Ayatollah Ali Khamenei, ending his 36-year rule. Retaliatory strikes by Iran against U.S. bases in the Middle East killed three U.S. service members.

Prospects of an escalation also led oil prices and energy companies’ shares to surge.

“It’s very much one of uncertainty at the moment that investors are grappling with,” said Patrick O’Donnell, Chief Investment Strategist at Omnis Investments.

“Equity markets are a little bit more uncertain about just how long this is going to drag on, for the implication for both growth and inflation that it will have the longer that it goes on,” O’Donnell told CNBC’s “Squawk Box Europe” on Monday.

“Really, it’s a question of… what’s the duration of this conflict?”

The conflict with Iran entered a third day on Monday, with U.S. President Donald Trump warning of further American casualties and saying the conflict could last for up to four weeks. 

In June last year, the U.S. and Israel launched air strikes that damaged three Iranian nuclear sites.

Carl Bildt, former Prime Minister of Sweden and co-chair of ECFR’s Council, said it was expected that Iran would strike back at the American military facilities in the Gulf region, “but now it seems like they are striking other targets across the Gulf as well.”

“That is surprising, but also highly disturbing, because, of course, the stability of the Gulf countries is important to us all, important to the global economy, important to the region,” he said.

European defense companies must take a stronger lead on collaborating to help the continent become independent of the U.S. security umbrella, Leonardo‘s CEO told CNBC.

Speaking with CNBC’s “Squawk Box Europe” on Wednesday after Leonardo’s annual results statement, Roberto Cingolani said European defense companies have “all the capabilities and technical skills” and should not wait for governments to fix the sector, which he warned was “fragmented.”

Companies should take the lead in a process of “aggregation”, which European governments would follow, he said, adding that this approach “pays a lot” and helps enable companies to become “better, faster, more profitable.”

He pointed to Leonardo’s partnership with the U.K.’s BAE Systems and Japan’s Mitsubishi Heavy Industries as co-founders of the Global Combat Air Programme (GCAP) to jointly develop the Tempest stealth fighter.  

Leonardo has also developed joint agreements with German defense giant Rheinmetall for land defense systems, and with Turkish drone maker Baykar, he said.

Last October, Leonardo also unveiled plans for a combined space and satellite company with Airbus and Thales to rival Elon Musk’s Starlink.

“I’m firmly convinced nobody can make it on their own,” Cingolani told CNBC. “We need to deploy synergies, we need to understand joining forces in a competitive industry like defense is fundamental to be successful, to be fast in responding to the needs of our societies.”

U.S. President Donald Trump’s bid to annex Greenland contributed to fractures in the NATO alliance, as the war in Ukraine focuses attention on Europe’s defense.

His comments came after Leonardo reported an 18% annual increase in core profits — topping 1.75 billion euros ($2.1 billion) — in its latest earnings statement on Wednesday.

New orders rose 14.5% last year, to 23.8 billion euros, powered by its aeronautics division, as net debt sat at 1 billion euros — a 44% decrease for the Rome-headquartered, Milan-listed company.

Its shares finished Wednesday’s session 3.5% down after the earnings.