Newswise — JACKSONVILLE, Fla. — Mayo Clinic researchers developed an experimental nanotherapy that delivers two cancer drugs directly to brain tumors, according to a study published in Nature Communications Medicine. The strategy extended survival in preclinical models of glioblastoma, the most aggressive form of brain cancer.

The nanotechnology-based approach packages two existing cancer drugs into tiny particles engineered to cross the brain’s protective blood-brain barrier and target tumor cells. In preclinical models using patient-derived tissue, combining the treatment with radiation more than doubled survival compared with untreated controls.

Glioblastoma is notoriously difficult to treat. Patients typically survive for about 15 months after diagnosis, even with the latest therapies such as surgery, radiation and chemotherapy. One major challenge is that many drugs cannot effectively reach tumors in the brain, and those that do often lose effectiveness as tumors develop resistance.

The new approach uses small lipid-based particles, known as liposomes, to carry and deliver a combination of drugs — everolimus or rapamycin and vinorelbine — directly to cancer cells, using a new tumor-targeting strategy. By ensuring both drugs reach the same cells at the same time, researchers aim to improve tumor-killing effects while reducing the toxic side effects associated with higher drug doses.

“Glioblastoma remains extremely difficult to treat due to drug resistance and limited drug delivery to the brain,” says Debabrata (Dev) Mukhopadhyay, Ph.D., a professor of biochemistry and molecular biology at Mayo Clinic in Florida. Dr. Mukhopadhyay, a nanotechnologist, is a senior author of the study. “Our approach is designed to improve both by targeting the tumor directly and combining therapies in a way that enhances their impact.”

The drug combination includes agents that interfere with tumor growth pathways and disrupt the cancer’s ability to repair DNA damage, making tumors more sensitive to radiation.

“This represents a promising direction for treating patients with glioblastoma and advancing new technologies and therapies, so we can one day improve the survival of patients with brain cancer by delivering novel cancer therapies to the brain,” says Alfredo Quinones-Hiñojosa, M.D., dean of research emeritus and chair emeritus of the Department of Neurosurgery at Mayo Clinic in Florida and a senior author on the study. “Further research will be needed to determine whether these results translate to patients.”

Researchers are conducting additional safety and dosing studies required before clinical trials can begin. If successful, the approach could eventually be an oral or intravenous medication used alongside standard treatments or as an option for patients whose tumors do not respond to existing therapies.

“While this work is still in development, it represents an important step toward developing more precise cancer treatments that are both more effective and less toxic, potentially improving quality of life for patients,” says Dr. Mukhopadhyay.

This study was supported in part by the National Institutes of Neurologic Disorders and Stroke of the National Institutes of Health under award number R01NS129671. Read the study for a full list of authors, disclosures and funding.

About Mayo Clinic

Mayo Clinic is a nonprofit organization committed to innovation in clinical practice, education and research, and providing compassion, expertise and answers to everyone who needs healing. Visit the Mayo Clinic News Network for additional Mayo Clinic news.

About Mayo Clinic Comprehensive Cancer Center

Designated as a comprehensive cancer center by the National Cancer Institute, Mayo Clinic Comprehensive Cancer Center is defining the cancer center of the future, focused on delivering the world’s most exceptional patient-centered cancer care for everyone. At Mayo Clinic Comprehensive Cancer Center, a culture of innovation and collaboration is driving research breakthroughs in cancer detection, prevention and treatment to change lives.

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Newswise — Liquid electrolytes enable fast ion transport but can raise safety concerns, and lithium metal anodes—despite their high capacity—can grow dendrites that trigger short circuits and rapid failure. Solid polymer electrolytes are attractive because they are processable and potentially compatible with lithium metal, yet many polymer systems (especially PEO-based) become highly crystalline at room temperature, restricting Li⁺ mobility. Adding plasticizers can improve conductivity, but excessive softening may weaken mechanical protection and destabilize interfaces. Meanwhile, strengthening the polymer often worsens ionic transport, leaving researchers stuck between conductivity and robustness. Based on these challenges, deeper research is needed to develop solid polymer electrolytes that simultaneously deliver high ionic conductivity and high mechanical strength.

Researchers at Zhejiang Sci-Tech University report a fiber-reinforced composite solid polymer electrolyte designed to overcome the long-standing “conductivity–strength” dilemma in polymer-based solid-state batteries. In a study published (DOI: 10.1007/s10118-025-3515-3) online on January 19, 2026 in the Chinese Journal of Polymer Science, the team shows that combining a porous PTFE fibrous membrane (as a reinforcing framework) with the plastic-crystal additive succinonitrile yields an electrolyte that is both mechanically robust and electrochemically effective for lithium metal battery operation.

The team’s concept borrows from structural engineering: a lightweight porous framework provides mechanical reinforcement, while the polymer phase supplies ion transport. They infiltrated a PEO/PVDF-HFP/LiTFSI matrix containing succinonitrile into a porous PTFE fibrous membrane via solution casting, aiming for uniform filling and intimate interfacial contact. Microscopy suggests the PTFE scaffold helps “hold” the electrolyte in a continuous network, while the succinonitrile component improves wetting and reduces PEO crystallinity—two factors expected to open faster Li⁺ pathways.

Material optimization mattered. At an optimized 20 wt% succinonitrile, the electrolyte achieved an ionic conductivity of 7.6×10⁻⁴ S·cm⁻¹ at 60 °C while retaining strong mechanical performance, reaching 3.31 MPa tensile strength with 352% elongation—a combination intended to resist dendrite penetration without sacrificing flexibility. Electrochemically, the composite sustained lithium symmetric-cell cycling for about 2,500 hours at 0.15 mA·cm⁻², indicating stable interfacial behavior during repeated plating/stripping. In Li//LiFePO₄ full cells, the electrolyte delivered durable cycling with 91.6% capacity retention after 300 cycles at 0.5C and coulombic efficiency consistently above 99.9%, supporting the claim that the composite design improves both stability and longevity.

According to the authors, the performance comes from a deliberate “division of labor” inside the composite. The PTFE fibrous membrane acts as a thermally stable, mechanically strong backbone that helps maintain structural integrity under cycling stress. Succinonitrile suppresses polymer crystallinity and promotes faster Li⁺ transport, while PVDF-HFP improves salt dissolution and contributes to electrochemical stability. Together, these components create a reinforced yet conductive electrolyte architecture that can be fabricated by straightforward casting and still deliver long-duration symmetric-cell stability and reliable full-cell cycling.

For solid-state lithium metal batteries to become practical, electrolytes must be manufacturable at scale, mechanically resilient, and consistently conductive—especially under conditions where dendrites are likely. This work points to a pragmatic materials strategy: instead of chasing a single “perfect” polymer, build composites in which a porous fiber scaffold provides structural protection and a carefully tuned additive accelerates ion transport. The demonstrated thousands-hour lithium cycling stability and strong capacity retention in LiFePO₄ full cells suggest potential for safer, longer-lived energy storage. If the approach translates to broader cathode chemistries and lower-temperature operation, it could help move polymer-based solid-state batteries closer to real-world deployment.

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References

DOI

10.1007/s10118-025-3515-3

Original Souce URL

https://doi.org/10.1007/s10118-025-3515-3

Funding information

This research was financially supported by the National Key Research and Development Program of China (No. 2021YFB3801500) and Fundamental Research Funds of Zhejiang Sci-Tech University (No. 24202105-Y).

About Chinese Journal of Polymer Science (CJPS)

Chinese Journal of Polymer Science (CJPS) is a monthly journal published in English and sponsored by the Chinese Chemical Society and the Institute of Chemistry, Chinese Academy of Sciences. CJPS is edited by a distinguished Editorial Board headed by Professor Qi-Feng Zhou and supported by an International Advisory Board in which many famous active polymer scientists all over the world are included. Manuscript types include Editorials, Rapid Communications, Perspectives, Tutorials, Feature Articles, Reviews and Research Articles. According to the Journal Citation Reports, 2024 Impact Factor (IF) of CJPS is 4.0.

Newswise — Near-field optical trapping has transformed particle manipulation in biology, chemistry, and nanotechnology, enabling contact-free control of objects ranging from nanoparticles to living cells. However, most existing whispering-gallery-mode and waveguide-based platforms rely on evanescent fields that penetrate only about 100 nanometers into the surrounding medium. This shallow interaction region restricts trapping efficiency and makes the system highly sensitive to perturbations caused by trapped particles themselves. Such instability limits practical applications requiring dense, large-area, or long-term manipulation. Given these challenges, it is necessary to develop optical trapping strategies that achieve deeper field penetration, stronger light–matter interaction, and greater robustness against particle-induced disturbances.

Researchers from Fudan University and The Hong Kong Polytechnic University report a new optical trapping platform in Microsystems & Nanoengineering, published (DOI: 10.1038/s41378-026-01167-7) in January 2026. The team demonstrates a gradient-thickness-protected microbottle resonator that enables large-scale, stable optical trapping via whispering-gallery modes. By introducing a controlled wall-thickness gradient into a hollow microbottle geometry, the device supports high-order axial modes that generate multiple optical trapping sites along its length. This design allows particles to be trapped efficiently over nearly 200 micrometers with ultralow optical power.

The core innovation lies in the microbottle resonator’s gradient wall thickness, which is thinnest at the equator and gradually thickens toward both ends. This geometry fundamentally changes how optical fields are distributed inside the resonator. Instead of confining particles to weak evanescent fields near the surface, the device generates strong optical-field antinodes that extend several micrometers into the liquid core, creating deep, stable trapping potentials.

The researchers show that this configuration supports high-order axial whispering-gallery modes, forming dozens of discrete trapping “orbits” along the resonator axis. Experiments demonstrate stable trapping of 500-nanometer-radius polystyrene particles across an axial span exceeding 195 micrometers, far larger than that of most near-field platforms. Remarkably, the trapping threshold power is only 0.198 milliwatts, highlighting the system’s energy efficiency.

Equally important, the gradient-thickness design protects the strongest optical fields by confining them within the silica wall at the resonator ends. This minimizes degradation of the optical quality factor when particles are trapped, ensuring consistent performance even during large-scale, multi-particle manipulation. The platform also supports localized, tunable trapping via standing-wave excitation, enabling precise repositioning of individual particles.

“This work shows that optical trapping performance is not only about stronger lasers, but about smarter structures,” the researchers note. “By engineering the resonator geometry, we can control where optical energy resides and how it interacts with particles.” They emphasize that isolating the peak optical fields from particle-induced perturbations is key to achieving robust and scalable trapping. The approach, they suggest, bridges the gap between laboratory demonstrations and practical optofluidic systems capable of handling complex, real-world samples.

The gradient-thickness microbottle resonator opens new possibilities for high-throughput and label-free particle manipulation. Its extended trapping range and multiple stable orbits make it suitable for parallel single-cell analysis, bioparticle sorting, and real-time monitoring of microbial dynamics. The rapid orbital motion of trapped particles can also enhance micromixing, potentially accelerating biochemical reactions in microfluidic environments. Beyond biology, the platform may enable advanced sensing, targeted drug delivery, and reconfigurable optofluidic devices. More broadly, the study highlights how geometric design can unlock new regimes of light–matter interaction, offering a versatile blueprint for next-generation optical manipulation technologies.

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References

DOI

10.1038/s41378-026-01167-7

Original Source URL

https://doi.org/10.1038/s41378-026-01167-7

Funding information

This work was financially supported by the National Natural Science Foundation of China (grant no. 62175035, X.W.), Natural Science Foundation of Shanghai (grant no. 21ZR1407400 X.W.), Hong Kong Research Grant Council/University Grants Committee (grant no. 21203724, L.K.C.) and the Hong Kong Polytechnic University (Global STEM Professorship BDA8, A.-Q.L.).

About Microsystems & Nanoengineering

Microsystems & Nanoengineering is an online-only, open access international journal devoted to publishing original research results and reviews on all aspects of Micro and Nano Electro Mechanical Systems from fundamental to applied research. The journal is published by Springer Nature in partnership with the Aerospace Information Research Institute, Chinese Academy of Sciences, supported by the State Key Laboratory of Transducer Technology.

Newswise — Lithium-ion batteries serve as the core energy storage devices in various industries and everyday products, including smartphones, electric vehicles, and ESS (energy storage systems). However, conventional lithium-ion batteries use liquid electrolytes, posing a risk of fire or explosion when subjected to external impact or overheating. Recent electric vehicle fire incidents have heightened concerns about their safety. As an alternative to overcome these limitations, ‘all-solid-state batteries’-which use non-flammable solid materials as electrolytes-are gaining attention as next-generation battery technology.

However, amorphous solid electrolytes-the core material for all-solid-state batteries-have faced limitations in analyzing lithium-ion transport mechanisms due to the irregularity of their internal structure. Consequently, performance improvements have been achieved empirically by altering electrolyte composition or compression conditions, making it difficult to systematically explain the causes of performance differences.

A research team led by Dr. Byungju, Lee at the Computational Science Research Center of the Korea Institute of Science and Technology (KIST, President Sang-Rok Oh) has identified key factors governing lithium ion movement in amorphous solid electrolytes through AI-based atomic simulations. The team analyzed lithium-ion movement by distinguishing it into ‘ease of movement between sites’ and ‘connectivity of movement paths’. They confirmed that overall performance is more significantly influenced by the difficulty of ions moving from one site to the next than by path connectivity.

In fact, while ion conductivity performance varied by up to fivefold depending on lithium ion mobility, the effect of pathway connectivity was limited to approximately a twofold difference. This provides a quantitative basis for interpreting performance variations that were previously difficult to explain due to the amorphous structure. Furthermore, the research team identified specific structural conditions that enhance lithium ion mobility. The higher the proportion of structures where four sulfur atoms surrounded a lithium ion, the faster the ion migration became. Optimal performance was achieved when the size of the internal void space fell within an appropriate range. Notably, excessively large voids actually hindered ion migration and degraded performance. This finding overturns the conventional wisdom that ‘lower density leads to higher conductivity’.

The results of this study can be directly applied to the design and manufacturing process of solid electrolytes for all-solid-state batteries. Simply controlling the internal structure by adjusting the electrolyte composition ratio or compression/molding conditions can improve ionic conductivity performance without requiring additional material changes, making it highly applicable in industrial settings. Furthermore, the analytical method proposed in this study can be extended to the development of various solid electrolyte materials. By pre-selecting high-performance candidate materials, it can dramatically enhance performance prediction and accelerate material development speed. This is expected to advance the commercialization of all-solid-state batteries in fields where safety and energy density are critical, such as electric vehicles and energy storage devices.

Dr. Byungju, Lee of KIST stated, “This research is significant in that it clearly identifies the key factors determining the performance of amorphous solid electrolytes.” He added, “As it presents design criteria enabling systematic improvement of material performance, we expect it to contribute to accelerating the commercialization of all-solid-state batteries.”

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KIST was established in 1966 as the first government-funded research institute in Korea. KIST now strives to solve national and social challenges and secure growth engines through leading and innovative research. For more information, please visit KIST’s website at https://kist.re.kr//eng/index.do

This research was conducted as part of KIST’s major projects and the Materials Global Young Connect Project (RS-2024-00407995), supported by the Ministry of Science and ICT (Minister Bae Kyung-hoon). The research findings were published in the latest issue of the international journal Advanced Energy Materials (IF 26.0, JCR field 2.5%).

Newswise — In medicine, security, nuclear safety and scientific research, X-rays are essential tools for seeing what remains hidden.

The materials used to create X-ray detectors can be rigid, expensive and laborious to produce. But new research led by FSU Department of Chemistry and Biochemistry Professor Biwu Ma is creating lower-cost, adaptable materials that could revolutionize X-ray detection technologies.

In two separate research studies, Ma’s group offers solutions to long-standing challenges in X-ray imaging. In the first study, published in Small, the team developed a new material that generates electric signals when exposed to X-rays, enabling direct X-ray detection. In the second study, published in Angewandte Chemie, the researchers used a related material to produce low-cost scintillators, which are materials that emit visible light when exposed to X-rays or other high-energy radiation.

“We have traditionally relied on inorganic materials for X-ray detection, but they are often rigid, expensive to manufacture and energy-intensive to produce, and they have many limitations,” Ma said. “What we have been trying to develop is a new class of materials that can address the issues and challenges faced by existing materials.”

In these studies, researchers created new hybrid materials composed of both organic and inorganic components, known as organic metal halide complexes (OMHCs) and organic metal halide hybrids (OMHHs). By tailoring the structures of these materials at the molecular level, the team enabled different forms of X-ray detection. This research represents a major step toward developing lower-cost, scalable and flexible X-ray detector technologies capable of overcoming key limitations of conventional inorganic systems.

Glassy OMHC films for direct X-ray detectors

Commercially available direct X-ray detectors are constructed using inorganic semiconductors, made from non-carbon materials, such as cadmium telluride (CdTe) and cadmium zinc telluride (CdZnTe). These materials contain toxic elements and require energy-intensive processing, making them expensive.

In the first study, the team demonstrated, for the first time, the use of OMHCs as a material for making direct X-ray detectors. These are materials composed of carbon-based semiconducting molecules that are bonded to metal halides, which are compounds made of metal and a halogen element. The specific OMHC compound developed by the team was created out of zinc, bromine, and a carbon-based molecule, enabling efficient X-ray absorption and electron transport within a single material.

Using a melt-processing approach, similar to melting plastics and allowing them to cool into a desired shape, the researchers transformed OMHC molecular crystals into amorphous, glass-like materials that can be molded into ready-to-use forms. They used these materials to make direct X-ray detectors that convert incoming X-rays into electrical signals.

Results

The resulting detectors produced strong electrical responses even at low X-ray exposure levels, making them more effective than detectors made from traditional materials. The team also evaluated the long-term stability of detectors made with the new material. After storing the detectors for four months under ambient conditions, testing showed they retained 98% of their initial performance.

OMHCs offer additional practical advantages. They are less expensive to produce than materials currently used in commercially available X-ray detectors because they can be synthesized from abundant and non-toxic raw materials. Moreover, the simple melt-processing method also makes device fabrication easier and more scalable than existing approaches.

“This is actually the first time these OMHC materials have been used to fabricate direct X-ray detectors,” said Ma. “They can be prepared in a low-cost way while delivering high performance. From a sustainability perspective, this new class of materials offer tremendous advantages over conventional materials.”

Bright, fast and flexible scintillators: X-ray components on fabric

In the second study, the team developed a new version of OMHH-based scintillators that exhibit high light yield and fast response, meaning they emit strong visible light and respond almost instantly when exposed to X-rays. OMHHs are similar to OMHCs, but a different type of chemical bond brings together organic components and metal halides into a single material.

The work builds on the team’s years of effort in the area since 2020, when they demonstrated the first ecofriendly OMHH scintillators. Earlier versions of OMHH scintillators relied on slow crystal growth processes that limited their size and flexibility, and their light emission faded relatively slowly. This latest generation of OMHH scintillators overcomes both challenges by eliminating the need for crystal growth and by dramatically speeding up the light response.

Results

By carefully designing the molecular structure, the team created a new amorphous OMHH material that shows fast response in nanoseconds. Unlike earlier versions of OMHH scintillators, in which light emission comes from metal halide centers and lingers for longer periods, the new material emits from the organic components of the material, exhibiting a faster response while maintaining excellent X-ray absorption and high light output.

Fast-response scintillators are especially important for advanced radiation detection and imaging. Their rapid light emission allows for clearer images, improved timing accuracy and reduced signal overlap, which are critical for applications such as medical imaging, security screening and real-time radiation monitoring.

The amorphous nature of the material also allows it to be easily processed into thin films and coatings. Using this approach, the team created fabric-based X-ray scintillators that can be integrated into clothing, enabling wearable and portable radiation detectors. These flexible scintillating fabrics represent a significant departure from traditional rigid detectors and open new possibilities for comfortable, adaptable and low-cost X-ray detection technologies.

Why it matters

While the two studies focused on different X-ray detection approaches, both used similar material design strategies to address major challenges in developing next-generation X-ray detection technologies.

FSU has begun filing patents to commercialize the technologies developed in Ma’s group and test them in real-world conditions. These advancements offer exciting and cost-effective solutions for next-generation X-ray detection technologies. Commercialization of these materials could benefit many fields, including medical imaging, security scanning, nuclear safety and more.

In addition to the team’s internal efforts, the group has collaborated with research institutions and industrial partners to explore diverse applications of these materials. These collaborations include Delft University of Technology (TU Delft) for photon-counting computed tomography, the University of Antwerp for luminescent dosimeters for radiotherapy, the University at Buffalo for pixelated X-ray imagers, and Qrona Technologies for X-ray microscopy technologies.

“The materials are very unique and were developed here at FSU,” Ma said. “We believe our materials and devices have tremendous potential to outperform existing technologies and address key challenges in the field.”

The research has been supported by federal funding from the National Science Foundation Division of Materials Research and Innovation and Technology Ecosystems. The lead authors of the two publications are Oluwadara Joshua Olasupo, who recently graduated with a Ph.D., and Tarannuma Ferdous Manny, a fourth-year graduate student. Collaborators from TU Delft and the University at Buffalo also contributed to the work. The research additionally involved high school students through the FSU Young Scholars Program.