High-dose shot can lower seniors’ risk of dementia by 55%



This might make you think twice about skipping your annual shot.

A new study suggests older Americans who get a high-dose version of a common vaccine may face a lower risk of developing Alzheimer’s dementia than those who stick with the standard jab.

The protective effect appears strongest in women — who are about twice as likely as men to develop the memory-robbing disease.

Alzheimer’s disease is the most common form of the dementia in the US. Prostock-studio – stock.adobe.com

The stakes couldn’t be higher.

Across the country, more than 7 million Americans are living with Alzheimer’s, a condition that claims more lives each year than breast and prostate cancer combined.

If current trends hold, that number is expected to hit a staggering 13 million by 2050, with a new case emerging every 33 seconds.

Now, scientists say the influenza vaccine might help slow that surge.

While the flu shot is recommended for nearly all Americans each year, since 2022 the CDC has encouraged adults 65 and older to get a version about four times stronger than what the general population receives.

The reason is simple: As we age, our immune systems naturally weaken, and studies show the high-dose shot does a better job protecting older adults from serious flu complications compared with the standard version.

In the US, 1 in 9 Americans aged 65 and older are living with Alzheimer’s disease. Rido – stock.adobe.com

Earlier research from UTHealth Houston found that seniors who got the standard flu shot were already 40% less likely to develop Alzheimer’s over a four-year period compared with those who skipped it.

The high-dose version, however, appears to supercharge that benefit.

In a study of nearly 200,000 adults age 65 and older, researchers found that the stronger shot cut Alzheimer’s risk by nearly 55% over about two years.

Both men and women saw a drop in risk, but women appeared to get longer-lasting and more consistent benefits, though researchers aren’t sure what drives the difference.

Looking ahead, scientists are trying to figure out exactly how the stronger flu vaccine may help fight Alzheimer’s.

One leading theory is that it boosts the immune system while tamping down inflammation in the brain, which is believed to play a key role in the disease’s development.

“Enhanced [flu vaccines] confer greater protection against influenza infection, thereby decreasing risk of severe illness and the associated systemic inflammation that can promote neuroinflammation and neurodegeneration,” the study authors wrote.

The flu vaccine may protect against inflammation thought to drive Alzheimer’s disease progression. Leigh Prather – stock.adobe.com

The research did have some limitations.

One possible factor is healthy-user bias. The scientists noted that people who get a high-dose flu shot may also be more proactive about their health in ways that could lower their dementia risk.

There were other gaps too, including missing information on mortality and socioeconomic factors.

Still, the findings align with a growing body of research that suggests certain vaccines may help protect the brain.

For example, recent studies suggest the shingles vaccine may not only lower the risk of dementia but also slow cognitive decline in people who already have it. Similar benefits have been seen with the RSV and Tdap vaccines.

The new flu shot findings come as vaccination rates continue to lag compared with pre-Covid levels.

In 2024, just 67.1% of Americans 65 and older got some form of the jab, down from 70.5% in 2019, according to CDC data.


Dear Abby: My family won’t get vaccinated to see my baby



DEAR ABBY: I am having a baby in five months. My doctor is recommending that anyone who visits the baby in the first three months be up to date on vaccines (Tdap, flu, COVID and RSV, if age 60-plus). We have decided to follow our doctor’s recommendations. 

Some of my family members are resistant to getting these vaccines and want us to consider other options, like testing and wearing a mask, which is not as safe. Also, it would be hard for younger kids to do — my niece is 3. Abby, we vaccinated our young children (3 and 5) at the time when our niece was born, as part of what my sister requested. 

I am already stressed about this situation and do not want to talk it to death with my family, and I have grown resentful because of it. In the past, I have set boundaries with my family, and most of them have not been understood or received well. Can you offer me some guidance? — EXPECTING IN WASHINGTON

DEAR EXPECTING: I am happy to try. When your baby arrives, the responsibility for its welfare will rest mostly on you, the mother. Follow your doctor’s medical advice to protect your child. If family members don’t want to respect your wishes and do what they must to avoid endangering your baby (as you did for them), realize you can’t change their minds, and keep your distance for the first three months. 

DEAR ABBY: For nearly five years, my adult daughter was a domestic violence victim. My husband and I have done everything to support her freedom and new path. However, during her journey, she claimed that I had been abusive to her as a child. I do not recall any action I took that could be considered abusive, nor does my husband or her siblings. 

I am finding it difficult to rationalize her recollection of events when she didn’t recognize her recent relationship was abusive. Anyhow, I’ve recommended individual and group therapy. However, I have not admitted to any abuse because it didn’t happen. We all feel she’s projecting her anger and resentment from this recent relationship onto me because I was honest from the beginning that I saw red flags. We had candid conversations about the offender prior to the separation. But she keeps defending him and blaming me for having inflicted pain and suffering on her. 

Please tell me what you suggest I do to resolve this situation, as it is destroying our family. — DUMBFOUNDED IN DELAWARE

DEAR DUMBFOUNDED: Your daughter appears to be a troubled individual. I’m glad that you suggested therapy. The kind I would recommend would be family therapy, in which every member has a chance to air their “truths.” When someone in an abusive relationship attempts to deflect blame from their abuser onto someone else, they may be avoiding reality. A licensed psychotherapist could help put your daughter back on the right track.

Dear Abby is written by Abigail Van Buren, also known as Jeanne Phillips, and was founded by her mother, Pauline Phillips. Contact Dear Abby at or P.O. Box 69440, Los Angeles, CA 90069.