A sign of Swiss pharmaceutical giant Novartis is seen on the top of a building at Novartis Campus in Basel, northern Switzerland, on Sept. 9, 2025.
Fabrice Coffrini | AFP | Getty Images
Novartis is planning to buy U.S.-based biotech Excellergy for up to $2 billion, betting on a next-generation allergy treatment that may prove to work faster and better than anything currently on the market, the Swiss pharmaceutical giant said Friday.
The acquisition will add Exl-111, an early-stage drug candidate, to Novartis’ existing allergy portfolio. It is the latest bolt-on deal in the company’s attempt to offset looming patent expirations.
It comes just a week after Novartis announced it is acquiring Synnovation subsidiary Pikavation Therapeutics for up to $3 billion to secure the rights to an experimental breast cancer drug.
Excellergy’s lead asset remains several years away from hitting the market. Novartis said it will pay the smaller biotech in both upfront and milestone payments, and the transaction is expected to close in the first half of 2026, subject to regulatory approvals.
Novartis stock traded sideways in morning trading in Zurich. Palo Alto-based Excellergy is privately held.
Shares of Novartis are up 33% over the past 12 months.
Many of the best-selling drugs in the world are facing a loss of exclusivity in key jurisdictions in what the sector calls “the patent cliff.” By the turn of the decade, companies risk losing hundreds of billions in revenue as branded drugs are exposed to generic competition.
Like the second half of 2025, early 2026 has seen a slew of M&A announcements from Big Pharma, including Merck announcing it has reached an agreement to buy Terns Pharmaceuticals for up to $6.7 billion earlier this week. Britain’s GSK and AstraZeneca are also among the companies that have announced several deals over the past months.
GSK’s global head of business development Chris Sheldon told CNBC late last year he is looking for acquisitions often in mid-stage development in the $1 billion to $2 billion range, where the biology is validated biology but the outcome of a drug candidate isn’t yet obvious. Like Novartis and AstraZeneca, GSK looks for so-called bolt-on deals that complement its portfolio and technology.
Novartis warned earlier this year that profits would decline in early 2026 as some of its best-selling drugs, including heart medicine Entresto face generic competition. Its second-best-selling medicine Cosentyx is expected to lose key exclusivities around 2029.
“For the first half of the year, we will have a tough prior year base with Entresto, Promacta and Tasigna generics having entered the U.S. market mid-2025,” said then-incoming CFO Mukul Mehta in a post-earnings call with analysts in February.
Novartis is seeing strong growth in other medicines such as cancer drug Kisqali and multiple sclerosis treatment Kesimpta, but still has to bulk up its pipeline to offset declines.
CEO Vas Narasimhan has said that the company is in the middle of the biggest patent expiration wave in the company’s history.
“It’s $4 billion that we will absorb over the course of this year across the three medicines,” Narasimhan told CNCB in February.
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The MSC Emma container ship on the dockside at the Port of Felixstowe in Felixstowe, UK, on Thursday, Nov. 20, 2025.
Bloomberg | Bloomberg | Getty Images
British companies are seeking deeper trade ties with Europe, business groups told CNBC, as U.S. President Donald Trump unveiled a sweeping 15% tariff on all imports after the Supreme Court struck down previous levies.
New tariffs would mark a 50% increase on the level negotiated last year in a trade deal between the U.K. the U.S., making the country one of the worst hit, according to analysis from think tank Global Trade Alert.
While U.S. Trade Representative Jamieson Greer said the administration “expects” to stand by trade deals, the U.K. government is reportedly in ongoing discussions with counterparts in America.
The seesawing uncertainty is increasingly forcing U.K. businesses to look to closer alignment with the European Union and European countries, as they hunt for predictable trade partnerships, groups which represent U.K. businesses told CNBC.
“There’s just no certainty or consistency and companies are very weary of this,” said William Bain, head of trade policy at the British Chambers of Commerce (BCC), which represents 50,000 businesses.
“They’re potentially looking at other options in terms of doing more trade with Europe or with the Indo-Pacific [region], where there seem to be less risk of fluctuations,” he told CNBC.
Uncertainty
Trump’s announcement that there would be blanket tariffs on all imports to the U.S. over the weekend brought further headaches to Europe’s business sector, which had seen the longstanding global trading order torn up last year.
In April, the U.S. upended the status quo by imposing a range of tariffs on trading partners across the world.
CNBC has approached the U.K.’s Department for Business and Trade and the U.S.’ Department of Commerce for comment.
“The U.S. is seen as increasingly unpredictable and there remains some concern about the EU’s growth as they strive to compete with the world’s main trading blocs,” said Emma Rowland, trade policy advisor at UK business group the Institute of Directors (IoD), which represents around 20,000 business leaders.
As a result, firms are looking to diversify supply chains or reconsidering the U.S. as a market altogether, Rowland told CNBC.
U.S. President Donald Trump inspected an honour guard during a welcome ceremony at Buckingham Palace in central London on June 3, 2019, on the first day of their three-day State Visit to the U.K.
Mandel Ngan | Afp | Getty Images
“On the whole, businesses have been supportive of the way that the [U.K.] government has pursued a balanced approach to the UK’s international trading partners,” Rowland said. “That being said, of those who would want the government to prioritise a trading relationship, business leaders would overwhelmingly choose closer alignment with the EU over the U.S.”
For U.K. businesses, the BCC estimates that the tariff increase will raise the cost of U.K. exports by between £2 billion ($2.7 billion) and £3 billion across a 12-month period.
“Many companies have, for example, 12 to 18 months timelines for contracts on supply of goods, and at this point there’s very few companies who can say what the tariffs will be and what prices they’ll be able to charge in six months time,” said Bain.
U.K. sectors that could be most impacted by Trump’s new tariffs — should they come into force on Feb. 24 at 12.01 a.m. E.T. as previously stated — are food and drink, clothing and footwear and electrical and industrial goods, Bain told CNBC.
The “majority” of the U.K.-U.S. deals on car, steel and pharma tariffs were not expected to change but discussions were ongoing, the BBC reported, citing an official spokesperson of U.K. Prime Minister Keir Starmer.
World leaders during the G7 Leaders’ Summit in Kananaskis, in Alberta, Canada, June 17, 2025.
Amber Bracken |Reuters
U.S. trading partners offered a cautious welcome to the U.S. Supreme Court’s decision Friday to strike down large parts of President Donald Trump’s flagship trade policy on global tariffs — but global trade bodies warned of lingering uncertainty surrounding import levies.
The law that undergirds the import duties “does not authorize the President to impose tariffs,” the majority ruled six to three in the long-awaited Supreme Court decision.
Hours after the ruling, Trump said he signed an executive order imposing a new 10% “global tariff”. The “Section 122” tariffs will take effect “almost immediately,” Trump said. At a White House press briefing Friday afternoon, Trump railed against the “deeply disappointing” 6-3 ruling.
Trump’s tariff regime impacted a swathe of countries from the U.K. to India and the European Union. Some governments, like Vietnam and Brazil are still in negotiations.
Taiwan, home to the the world’s leading contract chipmaker and producer of the most advanced semiconductors, said the 10% flat tariff rate would, according to an initial assessment, have a “limited impact” on its economy.
The island will continue to “closely monitor” developments and maintain close communication with the U.S. to understand the specific measures and respond in a timely manner, the Taiwanese cabinet said in a statement on Saturday.
French President Emmanuel Macron reportedly said the Supreme Court’s ruling proved the benefit of having an effective counterweight to power.
“It is not bad to have a Supreme Court and, therefore, the rule of law,” Reuters quoted him as saying at an event in Paris on Saturday.
A U.K. government spokesperson said the country would continue to work with the White House administration to understand how the ruling will affect tariffs for the U.K. and the rest of the world
“This is a matter for the U.S. to determine but we will continue to support U.K. businesses as further details are announced,” the spokesperson said.
“The U.K. enjoys the lowest reciprocal tariffs globally, and under any scenario we expect our privileged trading position with the U.S. to continue.” The U.K. agreed a wide-ranging trade deal with the U.S. in May last year, which imposed a broad 10% levy on many goods, but also included certain carve-outs on steel, aluminum, cars and pharmaceuticals.
The Supreme Court case focused mainly on reciprocal tariffs, and the ruling leaves much of the U.K.’s trade deal with the U.S. — including preferential sectoral tariffs on steel, pharmaceuticals and autos — unaffected.
However, the British Chambers of Commerce (BCC) trade body said the U.S. Supreme Court decision adds to the ongoing uncertainty around levies.
William Bain, head of trade policy at the BCC, said the move “does little to clear the murky waters” for British businesses, warning that the President still has “other options at his disposal” to retain his current regime on steel and aluminum tariffs.
“The court’s decision also raises questions on how U.S. importers can reclaim levies already paid and whether U.K. exporters can also receive a share of any rebate depending on commercial trading terms,” Bain said in a statement. “For the U.K., the priority remains bringing tariffs down wherever possible.”
Olof Gill, European Commission spokesperson for trade and economic security, said businesses on both sides of the Atlantic depend on “stability and predictability.”
“We remain in close contact with the U.S. Administration as we seek clarity on the steps they intend to take in response to this ruling,” Gill said. “We therefore continue to advocate for low tariffs and to work towards reducing them.”
Meanwhile, Dominic LeBlanc, Canada’s minister for U.S.-Canadian trade relations, said the decision “reinforces Canada’s position that the IEEPA tariffs imposed by the United States are unjustified.”
No trade ‘win’ yet
Elsewhere, Swissmem, Switzerland’s technology industry association, welcomed the ruling — but warned that the Trump administration could invoke other laws to “legitimize tariffs,” and called on Swiss policymakers to strengthen the competitiveness of the country with new free trade agreements.
“From the perspective of the Swiss export industry, this is a good decision. The high tariffs have severely damaged the tech industry. However, today’s ruling doesn’t win anything yet,” Swissmem said.
“The high tariffs have severely damaged the tech industry,” Swissmem wrote on X. “The crucial thing now is to quickly secure relations with the U.S. through a binding trade agreement.”
The International Chamber of Commerce noted that many businesses will welcome the ruling given the “significant strain” that has been placed on balance sheets in recent months.
“But companies should not expect a simple process: the structure of U.S. import procedures means claims are likely to be administratively complex. Today’s ruling is worrying silent on this issue and clear guidance from the Court of International Trade and the relevant U.S. authorities will be essential to minimise avoidable costs and prevent litigation risks,” the ICC said.
— CNBC’s Jackson Peck and Greg Kennedy helped contribute to this story.
This report is from this week’s CNBC’s UK Exchange newsletter. Like what you see? You can subscribe here.
The dispatch
Compass is that rare beast — a British company that is a genuine world leader in its field.
The world’s biggest contract caterer, which annually serves 5.5 billion meals in schools, colleges, workplaces, hospitals and sporting venues in more than 25 countries, is considered a well-run business.
Accordingly, its trading updates tend not to excite, routinely consisting of news on organic sales growth, margin improvements and — with workplace catering operations gradually being outsourced around the world — new business wins.
Last week’s update, though, brought something more eyebrow-raising as Compass announced that, from April 1, it will change the currency in which its shares are traded from sterling to the U.S. dollar.
The company explained that having reported in dollars since October 2023, the measure would align its share price trading currency with its reporting currency, “reducing FX volatility in the share price and simplifying the investment case for global investors.”
A large scale sample of the new twenty pound note featuring late British painter JMW Turner is seen during the launch event for the new note design at Turner Contemporary gallery in Margate, south eastern England, U.K., on October 10, 2019.
Leon Neal | Afp | Getty Images
Cue hand-wringing over how Compass — which derives around three-quarters of its revenues in dollars — could be the next big U.K. company to abandon London for the New York Stock Exchange.
Protests from Compass that it would continue to pay dividends in sterling, unless shareholders elect to receive them in dollars, fell on deaf ears.
Compass was, in fact, taking advantage of a relatively recent change to the so-called “ground rules” governing membership of indices overseen by FTSE Russell, part of LSEG, the owner of the London Stock Exchange.
Announced in March 2025, and coming into force last September, it allowed for companies whose shares trade in dollars or euros “to be considered for potential inclusion to the FTSE U.K. Index Series.”
In doing so, London has shown considerably more flexibility than some other major financial centers. The New York Stock Exchange, for example, insists that all NYSE-listed shares are quoted, traded and settled exclusively in dollars.
The first company to take advantage of the rule change, in January this year, was InterContinental Hotels Group, the parent of the Holiday Inn and Crowne Plaza hotel brands, which derives some 80% of its revenues and operating profits in dollars. If anything, it is even more British than Compass, dating back 249 years in the country. It is also proud of having registered the U.K.’s first trademark — the famous Bass red triangle — in 1875.
‘The accounts were not acceptable’
In a sense, changing the currency in which a company’s shares are traded is the logical next step in a process that began many years ago.
When companies were allowed to publish their report and accounts in currencies other than sterling, many started to do so. The three biggest companies in the FTSE 100 by market capitalization — HSBC, AstraZeneca and Shell — all now report in dollars. Unilever, the fourth largest, reports in euros. Others in the FTSE’s top 20 reporting in dollars include the miners Rio Tinto, Glencore and Anglo American, the oil major BP and the international bank Standard Chartered.
It is not a recent development. As long ago as 1989, the car rental company Avis Europe began accounting in the old European Currency Unit (ecu), the synthetic currency which later evolved into the euro.
The move caused some complications for the business at the time. Alun Cathcart, the chairman and chief executive, told the annual Ecu Banking Association meeting at Copenhagen in June 1991 that, when Avis Europe had first submitted its report and accounts for 1990-91, the U.K. authorities refused to accept them.
He recounted: “We were asked to produce coins and notes, and if we couldn’t, the accounts were not acceptable.
“They were prepared to accept a report in Icelandic crowns or Australian dollars, but not in ecu.”
When in April 1997, Avis Europe floated on the stock market, it became the first London-listed company to report in ecus.
At the time, though, Avis Europe was very much an outlier. Other U.K. corporate stalwarts have only made the switch relatively recently. Shell began reporting its results solely in dollars at the beginning of 1998, explicitly doing so to encourage meaningful comparisons with U.S. rivals, with BP following suit a year later.
In the same sector, BG Group, the gas exploration and production company spun out of the old British Gas and acquired by Shell in 2015, began dollar reporting in 2009.
All were beaten by Rio Tinto, which has been listed longer in London than any other of the major global mining companies. It embraced the greenback following the merger in late 1995 of the old London-listed Rio Tinto Zinc (RTZ) and its 49%-owned Australian associate Conzinc Riotinto of Australia (CRA).
So it is surprising that the announcement from Compass last week caused such pearl-clutching. Perhaps the bigger surprise should be that British multinationals like GSK, British American Tobacco, Rolls-Royce, Diageo, RELX and Reckitt Benckiser, despite making most of their money overseas, remain loyal to the good old pound.
Top TV picks on CNBC
Greg Stafford, Conservative MP, discusses the mounting pressure on U.K. Prime Minister Keir Starmer.
Jack Meaning, U.K. chief economist at Barclays, discusses the market implications of the political pressure on Starmer, and the economic outlook after the latest Bank of England decision.
Andrew Bailey, governor of the Bank of England, discusses the Monetary Policy Committee’s latest decision to hold rates at 3.75% as global uncertainty weighs.
Need to know
UK’s latest political standoff threatens to put a ‘Damocles sword’ over the country’s bond market, Jordan Rochester, head of FICC strategy at Mizuho EMEA, said in a Monday note. The prospect of a leadership challenge could upend the policy path laid down by Starmer and his finance minister, Rachel Reeves, which poses a significant risk to gilt investors.
Jeffrey Epstein has sparked a political crisis threatening the UK government. The release of further Epstein files last week triggered a series of events that left U.K. Prime Minister Keir Starmer fighting for his political life, despite the fact that he never knew the late financier and sex offender.
China lashes out at the UK’s expansion of a scheme for Hong Kong residents to apply for the British National Overseas, or BNO visa, calling it “despicable” and “reprehensible.” The U.K.’s move comes after a Hong Kong court sentenced pro-democracy media tycoon Jimmy Lai to 20 years in prison under a national security law.
Quote of the week
Labour seem to be mystified and terrified of the bond market in equal proportions.
— Kallum Pickering, chief economist, Peel Hunt
In the markets
The FTSE 100 has traded lower over the past week, closing Tuesday at 10,353.84, compared to 10,402.34 a week ago. Britain’s blue-chip index finished yesterday’s session down about 0.3% on the day.
The British pound, meanwhile, rose slightly against the dollar this week, trading at $1.3665, up from $1.3650 last Wednesday, as yields on the U.K. government’s benchmark 10-year bonds — also known as gilts — dipped over the same period, finishing Tuesday at 4.495%, compared to 4.552% a week ago.
The performance of the Financial Times Stock Exchange 100 Index over the past year.
