“Today” show host Savannah Guthrie and her siblings released a new video on Saturday pleading for the return of their missing mother and saying, “We will pay.”

“We received your message and we understand,” Guthrie said in the brief video posted to Instagram. “We beg you now to return our mother to us so we can celebrate with her. This is the only way we will have peace. This is very valuable to us, and we will pay.”

Nancy Guthrie, 84, was last seen Jan. 31, and authorities have said they believe she was abducted from her home.

“We are aware of the video posted by the Guthrie family. But don’t have any additional information to share,” a spokesperson for Pima Sheriff said in a statement to ABC News on Saturday following the release of the latest video from the family.

The message Savannah Guthrie references in her new Instagram post is the same message the FBI and Pima Sheriff said they were studying Friday, according to a source familiar with the investigation.

Investigators still have not confirmed the authenticity of the latest message which was received by a Tucson television station, nor any of the other ransom notes mentioning Nancy Guthrie, according to the source.  

However, investigators continue to take all of the messages seriously. 

There are no new leads that developed Saturday, the source said, echoing an earlier statement from the Pima County Sheriff’s Department 

The FBI is offering a $50,000 reward for information that could lead to the recovery of Nancy Guthrie and/or an arrest and conviction in her abduction. 

Nancy Guthrie was dropped off at home in the Catalina Foothills area north of Tucson, Arizona, shortly after 10 p.m. on Jan. 31, after having dinner with her family, according to authorities. She was reported missing the next morning after she did not show up to church, according to authorities. 

A doorbell camera at her home was disconnected at about 1:45 a.m. Sunday morning, authorities said. Shortly before 2:30 a.m. her pacemaker app indicated it was disconnected from her phone, according to authorities. 

Her blood was also found on the porch of her home, according to the sheriff. 

Investigators have not identified a suspect or person of interest in the case, Pima County Sheriff Chris Nanos said during a press briefing on Thursday.

Ransom notes have been sent to several local and national media outlets, according to the FBI. 

Prior to the video on Saturday, Savannah Guthrie and her siblings have posted other videos urging their mother’s suspected kidnappers to make contact with them and provide proof she is still alive.

ABC News’ Aaron Katersky and Trevor Ault contributed to this report.

President Donald Trump shared on his social media platform late Thursday night a video that included a racist animation of former President Barack Obama and former first lady Michelle Obama depicted with the bodies of apes.

After backlash, the White House at about noon Friday said the post had been taken down from the president’s page.

The roughly minutelong video, shared by Trump at 11:44 p.m. ET on Thursday, largely focused on debunked claims about the 2020 election.

At the end of the video, the Obamas’ faces appear abruptly and without explanation for seconds with the song “The Lion Sleeps Tonight” playing over it. The video then ends back on similar imagery of the conspiracy video footage. 

The Obamas had no comment when ABC News reached out to their representatives for a response.

White House press secretary Karoline Leavitt, when first asked for comment early Friday, had said, “This is from an internet meme video depicting President Trump as the King of the Jungle and Democrats as characters from the Lion King. Please stop the fake outrage and report on something today that actually matters to the American public.”

Though later Friday afternoon, a White House official told ABC News that a “staffer erroneously made the post.”

The video reposted by Trump overnight included only imagery of the Obamas.

The meme video referenced by Leavitt was shared in October by the Hardin County Republican Party of Kentucky on Facebook, which led the chairman to issue an apology and deleted the post after swift backlash noting the long history of racist tropes depicting Black people as apes or monkeys — a tool of slave traders and segregationists to dehumanize them.

Trump’s overnight repost was condemned by lawmakers on Capitol Hill, some of whom had called for it to be taken down and for the president to apologize.

House Democratic Leader Hakeem Jeffries, the first Black leader of a party in Congress, wrote on X: “President Obama and Michelle Obama are brilliant, compassionate and patriotic Americans. They represent the best of this country. Donald Trump is a vile, unhinged and malignant bottom feeder.”

“Every single Republican must immediately denounce Donald Trump’s disgusting bigotry,” Jeffries wrote.

Republican Sen. Tim Scott, the only Black Republican in the Senate and also the head of the National Republican Senatorial Committee, posted on X: “Praying it was fake because it’s the most racist thing I’ve seen out of this White House. The President should remove it.”

Republican Sen. Roger Wicker wrote in a post: “This is totally unacceptable. The president should take it down and apologize.”

Senate Minority Leader Chuck Schumer, a Democrat, wrote in a post: “Racist. Vile. Abhorrent. This is dangerous and degrades our country — where are Senate Republicans? The President must immediately delete the post and apologize to Barack and Michelle Obama, two great Americans who make Donald Trump look like a small, envious man.” 

LONDON — Negotiating teams from the United States and Iran are expected to meet on Friday in Oman, marking a reopening of nuclear talks following weeks of tensions and threats, as leaders in Tehran oversaw a deadly crackdown on widespread protests. 

The U.S. side will be led by President Donald Trump’s Middle East envoy, Steve Witkoff, and Trump’s son-in-law Jared Kushner, according to the White House.

“The President has obviously been quite clear in his demands of the Iranian regime,” Karoline Leavitt said on Thursday during a press briefing. “Zero nuclear capability is something he’s been very explicit about.”

Iranian state-run media published photos and videos early on Friday of Foreign Minister Abbas Araghchi in the Omani capital, where he met with his local counterpart.

“Iran enters diplomacy with open eyes and a steady memory of the past year. We engage in good faith and stand firm on our rights,” Araghchi said on social media on Friday.

The talks, which were expected to begin at 10 a.m. local time, followed weeks of escalating tension between the U.S. and Iran, fueled in part by massive protests that have roiled Iran.

Those protests began in Tehran in late December in response to the collapse of the Iranian currency and the worsening of economic conditions, and then quickly took on a political character — with crowds on the streets openly calling for regime change.

Iranian authorities responded by launching a brutal crackdown on protests, according to observers. At least 6,495 protesters, along with hundreds of members of the state’s security forces, have been killed, according to the U.S.-based Human Rights Activist News Agency, an activist group. The group said it was reviewing thousands of other cases of possible deaths. ABC News cannot independently verify those figures.

As those protests escalated in January, Trump voiced concern for the protesters, saying, “I have cancelled all meetings with Iranian Officials until the senseless killing of protesters STOPS. HELP IS ON ITS WAY.”

Trump later in January said a “massive Armada” was heading toward the region. He warned Tehran to make a nuclear deal, saying another U.S. attack would be “far worse” than the U.S. strike on nuclear sites within Iran in June of last year.

The Iranian foreign minister responded by saying the country’s military had “their fingers on the trigger.”

Those tensions had to some extent begun to thaw by last week, when Iran’s president, Masoud Pezeshkian, said he had instructed Araghchi to pursue “fair and equitable” talks with Washington. The White House had sought help from regional allies, who assisted in bringing Iran back to the negotiating table, according to both countries.

Araghchi said on Friday that any commitments made between the two countries “need to be honored,” adding, “Equal standing, mutual respect and mutual interest are not rhetoric — they are a must and the pillars of a durable agreement.”

Members of the Trump administration last held a series of nuclear talks with Iran in April and May 2025 in Oman. A round of those talks planned for June was scuttled after Israel launched aerial strikes on Iran, an attack that the U.S. later joined.

Senior U.S. officials have continued publicly voicing concerns about the Iranian leadership in the days since the latest round of talks were announced.

“The Iranian regime does not reflect the people of Iran, nor their culture rooted within a deep history,” Secretary of State Marco Rubio said on Thursday. “I know of no other country where there’s a bigger difference between the people who lead the country and the people who live there.”

The virtual U.S. Embassy in Iran posted on Thursday a security alert again calling for all U.S. citizens to depart Iran, provided it’s safe for them to do so. 

“If you cannot leave, find a secure location within your residence or another safe building,” the alert said.

Leavitt on Thursday said Trump was seeking a deal with Iran, but, she added, “I would remind the Iranian regime that the President has many options at his disposal, aside from diplomacy, as the commander in chief of the most powerful military in the history of the world.”

President Donald Trump on Thursday unveiled his TrumpRx website in an event at the White House, listing 40 drugs at lower cost than previous list prices to patients paying out of pocket and calling the launch part of the “most transformative health care initiatives.”

Trump made the announcement alongside Centers for Medicare and Medicaid Services Administrator Dr. Mehmet Oz and National Design Studio Director Joe Gebbia.

“Starting tonight, dozens of the most commonly used prescription drugs will be available at dramatic discounts for all consumers throughout a new website is called TrumpRx.gov,” Trump said at the White House event.

Some of the reduced cash prices were announced last year by the administration and some of the new prices had already gone into effect. 

The president touted the use of his Most Favored Nation (MFN) policies — making sure the U.S. isn’t paying more than other countries — for making the lower prices possible.

“For years, politicians from both parties have promised to bring down prescription drug prices and make health care more affordable, but they all failed,” Trump said.

According to the TrumpRx website, these drugs can be obtained at participating pharmacies using coupon card codes displayed on the website or directly through manufacturers’ websites.

The website also notes that “TrumpRx discounted pricing is only available for cash-paying patients,” in a FAQ section. The discounts are not available for patients trying to pay through insurance and do not go toward insurance deductibles.  

Only a few dozen drugs are offered on the website, though the website says that “many more drugs are coming soon,” in a FAQ section.

What some experts are saying

“It’s nice that they are aggregating coupons in one place,” Benjamin Jolley, PharmD, a senior fellow for health care at the American Economic Liberties Project told ABC News. “But it’s a convenience to check the website to see the coupons all in one place for the first time.

Dr. Christina Madison, the founder of The Public Health Pharmacist told ABC News: “There are a lot of patient assistance programs out there and this appears similar to programs like GoodRX but the difference here is that you would not have to go through the manufacturer’s website to get them.”

In a statement, Good RX tells ABC News they are a key integration partner for pharma companies that is offering discounted cash prices on TrumpRX, “The self-pay price is hosted on the GoodRx platform and GoodRx then integrates the price into TrumpRx.” 

GoodRX-provided codes can currently be used at over 70,000 retail an home delivery pharmacies.

How much will consumers save?

Trump said the discount offers “tremendous” savings.

But experts say the overall savings are not clear and may only benefit a certain group of people. 

“TrumpRx’s offerings are very limited, fewer than 50 drugs listed,” Rena Conti, an associate professor at the Boston University Questrom School of Business, told ABC News.

“This suggests it pays for consumers to check their insurance coverage and ask their regular doctor or pharmacist before they use this service,” Conti added. 

The website boasted savings on GLP-1s, showing that the Wegovy pill’s lowest TrumpRx price was $149 a month, slashed from what the website says is an original price of $1,349. And while the full cash price of Ozempic and Wegovy (FDA approved for weight loss) did start at over $1,000 a month, those prices have been slowly going down in price. It was reduced voluntarily first to $499 in March 2025 and then to $199 in November after negotiations with the federal government.

Some drugs remain very expensive, including Xeljaz, which is marked at a starting price of $1,518, despite a 50% savings. 

Fertility drugs

One of the big categories of drugs included in TrumpRx are fertility drugs. 

According to the website, Gonal-F is available for an 83% discount, down from $966 to just $168 for the pen. Another IVF drug, Cetrotide, is offered at a 93% discount. And Ovidrel is offered for a 67% discount.  

“One in three families is having trouble having a baby. We’re gonna have a lot of Trump babies with these costs, folks cannot afford these medications. It’s gonna change their lives,” Oz said during the White House event.

“The fertility drug discount is legitimately a big deal for people trying to get IVF,” Jolley said. “These medicines are quite expensive and this seems like a big discount. In general IVF is not covered by insurance and so people prior to this who needed certain drugs would be paying the full $1400 price.”

Jolley noted for example, that the price slash on certain fertility drugs could lower the cost of an IVF cycle by about 20% overall. 

Trump first revealed his administration’s goal of launching the website back in September when he announced that Pfizer had agreed to lower its prices for prescription drugs offered through Medicaid.  Pfizer so far is the largest participant in Trump RX with over 30 medications listed. 

Trump last month released his “Great Healthcare Plan,” in which he called on Congress to codify the “most favored nation” initiative.

The plan also proposed sending money directly to Americans to buy health insurance and included calls to increase price transparency and hold insurance companies accountable — though it largely lacked specifics.

Polls show most Americans are concerned about health care costs.

A survey last month from KFF, a nonprofit health policy research organization, found two-thirds of U.S. adults worried about being able to afford health care for them and their family — outranking other expenses like gas and groceries. A majority of Americans, 56%, said they expect health care to become less affordable in the coming year.

The poll also found that two-thirds of Americans said Congress “did the wrong thing” by allowing enhanced Affordable Care Act tax credits to expire. Millions of Americans were expected to face increased premium costs as a result of the lapse.

ABC News’ Eric Strauss, Michelle Stoddart, Emily Chang and Isabella Murray contributed to this report.

The urgent search for Nancy Guthrie, the mother of “Today” show host Savannah Guthrie, has entered its fifth day, as her children continue to plead for her safe return.

Nancy Guthrie is believed to have been abducted in her sleep from her Arizona home early Sunday, authorities said. No suspect or person of interest has been identified in the case, and authorities do not know where she is or whether she was targeted, Pima County Sheriff Chris Nanos has said.

The Pima County Sheriff’s Department is set to hold a briefing on the case at 1 p.m. ET on Thursday.

Nancy Guthrie, 84, was last seen at her home in the Catalina Foothills area, north of Tucson, on Saturday night, according to the Pima County Sheriff’s Department. Her family reported her missing on Sunday around noon local time after she failed to show up to church, authorities said.

Savannah Guthrie and her siblings made an emotional plea for their mother’s return in a video message posted to social media on Wednesday.

“Everyone is looking for you, Mommy, everywhere,” Savannah Guthrie said in the video message. “We will not rest. Your children will not rest until we are together again.”

Nancy Guthrie is described as having some physical ailments and limited mobility, but does not have cognitive issues, according to the sheriff. She takes medication that if she doesn’t have in 24 hours, “it could be fatal,” Nanos said.

“Our mom is our heart and our home,” Savannah Guthrie said in the video. “She is 84 years old, her health, her heart is fragile. She lives in constant pain. She is without any medicine. She needs it to survive. She needs it not to suffer.”

The sheriff’s department said it is reviewing possible ransom notes as part of the investigation. ABC Tucson affiliate KGUN said it received one of the letters, which it forwarded to law enforcement. Officials say they are investigating if any of these letters are legitimate.

Addressing reports of a ransom letter, Savannah Guthrie said Wednesday, “As a family, we are doing everything that we can. We are ready to talk. However, we live in a world where voices and images are easily manipulated. We need to know without a doubt that she is alive and that you have her. We want to hear from you and we are ready to listen. Please reach out to us.”

The FBI is helping in the investigation. The agency is sending additional agents and experts to Pima County to help reinforce efforts on the ground and to aid local investigators, sources told ABC News on Wednesday.

Nanos said earlier this week that investigators were waiting to get surveillance footage from the home’s security cameras from the companies that own them.

A Google spokesperson confirmed to ABC News on Thursday that the company, which is behind Nest home security cameras, is assisting law enforcement in the investigation. The spokesperson declined to elaborate, citing the ongoing investigation.

Anyone with information is urged to call 911 or the Pima County Sheriff’s Department at 520-351-4900.

A partial government shutdown has recently come to an end, but another one may be on the horizon if Democrats and Republicans can’t hammer out an agreement on potential restrictions to put on immigration enforcement tactics that have been put in the spotlight after two fatal shootings by federal law enforcement in Minneapolis last month.

A day after House Minority Leader Hakeem Jeffries and the overwhelming majority of his caucus voted against a funding deal Senate Democrats had struck with the White House, Democratic leaders presented a unified message as they laid out their demands for reform at the Department of Homeland Security — calling on Republicans to “get serious” as lawmakers face a Feb. 13 deadline to fund the agency.

“The House and Senate are completely and totally on the same page in terms of Democrats,” Jeffries told reporters Wednesday. “Leader Schumer and I had a close, positive conversation yesterday about the path forward.”

Senate Minority Leader Chuck Schumer said they “had a really good and productive meeting, and we’re on the same page.”

As Jeffries and Schumer steady themselves for bipartisan negotiations, both leaders appeared eager to capitalize on the public backlash against the Trump administration’s immigration enforcement actions.

Democrats called to separate the DHS funding following the deaths of Renee Good, a mother of three who was fatally shot by an immigration enforcement officer in Minneapolis on Jan. 7, and became more urgent after the death of Alex Pretti, an ICU nurse, who was killed in a shooting involving federal law enforcement in Minneapolis on Jan. 24.

Sixty-two percent of Americans say current efforts by ICE to deal with unauthorized immigration go too far, according to polling conducted by Ipsos Jan. 30 to Feb. 1. 

Democrats lay out 10 key demands for DHS funding

In a letter Wednesday to Republican leaders, Jeffries and Schumer laid out 10 key demands from Democrats on DHS funding, including calling for judicial warrants before agents can enter private property, a ban on Immigration and Customs Enforcement wearing face masks, requiring the use of body cameras and new laws for use-of-force standards.

“Furthermore, there are steps that the Trump administration has the power to take right now to show good faith, including fully ramping down the surge in Minnesota and removing Secretary of Homeland Security Kristi Noem from her position,” Jeffries and Schumer wrote in the letter.

In remarks earlier Wednesday, Sen. Patty Murray, the top Democratic appropriator in the upper chamber, said “Democrats are at the table. We are focused on getting a bill, but it has to be a bill that reins in the abuses that we are seeing by ICE and CBP.”

Still, bipartisan negotiations did not commence Wednesday, and Speaker Mike Johnson sent the House on recess a day early on Wednesday afternoon. 

“The bottom line is we’re ready to sit down and negotiate,” Schumer said earlier. “If [Republicans are] not serious and they don’t put in real reform, they shouldn’t expect our votes. Plain and simple.”

In earlier remarks, Schumer and Jeffries seemed unsure whether they’re negotiating with President Donald Trump or congressional Republicans — with Schumer reporting that Senate Majority Leader John Thune told Democrats to talk to the White House. 

“Both are afraid of their shadows, and they’re getting a lot of blowback and pressure from their left,” Thune said of Jeffries and Schumer, according to Bloomberg, with Thune adding he hadn’t received an offer from Democratic leaders as of Wednesday morning.

“Thune is scared of his own shadow,” Jeffries told reporters early Wednesday afternoon. “We are negotiating because we want to try to achieve an outcome, but the changes that are enacted with respect to the way in which the Department of Homeland Security is conducting itself need to be bold, meaningful and transformative.”

The GOP response

Johnson said that Democrats “want to have a judicial warrant on top of the immigration judge warrant. And we can’t do that,” noting time constraints.

Johnson has signaled a “good faith” willingness to compromise on body cameras, but was adamant that Republicans would not support a ban on face masks for agents. 

“When you have people doxing them and targeting them, of course, we don’t want their personal identification out there on the streets, and so we’ve got to work through this in a meaningful way, in a thoughtful way that comports with common sense,” Johnson said Sunday.

Exit ramps

So far, Democrats have not put their proposal into legislative text.

Republicans have also not crafted any legislation so far to address next week’s deadline.

“Let’s hope that over the next two weeks, we can negotiate and get this done,” Johnson told reporters on Tuesday. “[Democrats] say they want a real negotiation with President Trump and Republicans over immigration enforcement policy, and we are happy to have that debate.”

Jeffries told reporters that he is a “hard no” on a continuing resolution for Homeland Security through the end of the fiscal year.

“We need to resolve this issue by Feb. 13,” Jeffries said. “American citizens are being killed in the streets. Children are being kidnapped. Houses of worship, schools and hospitals are being stormed. We need to get this done and get this done immediately.”

Democrats predicated that Republicans are setting the stage for a shutdown.

“Mike Johnson has articulated unreasonable positions,” Jeffries said. “He’s actually supporting the notion that masked and lawless ICE agents should be deployed in communities throughout America. That’s Mike Johnson’s position. That’s contrary to what the American people believe should be taking place.”

Johnson told reporters that he was heading to the White House later Wednesday to talk to the president. 

“We’ll see how it all develops,” Johnson said. 

What is the impact of shutting down DHS next week?

The DHS appropriations bill funds far more than ICE, despite ICE getting most of the attention in this current standoff. The bill also funds Transportation Security Administration, FEMA, the Coast Guard and the Secret Service, among other federal agencies.

While there is some FY2026 funding for ICE, the agency received a $75 billion infusion of funding over the next decade through the already-passed “Big Beautiful Bill,” so a lapse in funding at DHS would not cease operations there.

“What they’ll be shutting down is FEMA operations, as we’re cleaning up from the winter storm. They’ll be shutting down TSA, which is obviously necessary to keep the country moving through our airports. Coast Guard operations,” Johnson said of Democrats’ actions. “I mean, so many important functions in the Department of Homeland Security is what will be adversely affected by these partisan games. Let’s hope and pray that they don’t do that. Let’s hope that over the next two weeks, we can negotiate and get this done.”

“Today” show host Savannah Guthrie and her siblings made an emotional plea for the return of their mother, who remains missing days after police believe she was abducted from her home in Arizona.

“Everyone is looking for you, Mommy, everywhere,” Savannah Guthrie said in a video message posted on Wednesday alongside her sister and brother. “We will not rest. Your children will not rest until we are together again.”

Savannah Guthrie made an urgent plea for her mother’s return, citing the 84-year-old’s fragile health.

“Our mom is our heart and our home,” Savannah Guthrie said. “She is 84 years old, her health, her heart is fragile. She lives in constant pain. She is without any medicine. She needs it to survive. She needs it not to suffer.”

No suspect or person of interest has been identified in the case, the sheriff’s department said on Wednesday.

The sheriff’s department said it is reviewing possible ransom notes as part of the investigation. ABC Tucson affiliate KGUN said it received one of the letters, which it forwarded to law enforcement. Officials say they are investigating if any of these letters are legitimate.

Addressing reports of a ransom letter, Savannah Guthrie said Wednesday, “As a family, we are doing everything that we can. We are ready to talk. However, we live in a world where voices and images are easily manipulated. We need to know without a doubt that she is alive and that you have her. We want to hear from you and we are ready to listen. Please reach out to us.”

In a post on his social media platform on Wednesday night, President Donald Trump said he spoke with Savannah Guthrie and said he was “directing ALL Federal Law Enforcement to be at the family’s, and Local Law Enforcement’s, complete disposal, IMMEDIATELY.”

The post went on to say: “We are deploying all resources to get her mother home safely. The prayers of our Nation are with her and her family. GOD BLESS AND PROTECT NANCY!”

FBI Director Kash Patel was expected to be in Arizona to help oversee the investigation, according to multiple officials familiar with the matter. In addition to the FBI, an elite Border Patrol was helping with the investigation, according to multiple officials.

The FBI did not respond to ABC News’ request for comment.

Nancy Guthrie was last seen at her home near Tucson on Saturday night, according to the Pima County Sheriff’s Department.

Investigators do not believe Nancy Guthrie left her home willingly and said it appears she was abducted in her sleep early Sunday morning, the Pima County Sheriff’s Department told ABC News.

Nancy Guthrie’s family reported her missing on Sunday around noon local time, authorities said.

“We don’t know where she is,” Pima County Sheriff Chris Nanos said told reporters on Tuesday.

“We do believe that Nancy was taken from her home against her will, and that’s where we’re at,” he said.

The FBI is sending additional agents and experts to Pima County, Arizona, to help reinforce efforts on the ground and to aid local investigators in the case, sources told ABC News on Wednesday.

Among those being sent is a supervisor who will run a task force with experts in areas like hostage negotiation, data storage systems/networks and secure digital devices, the sources said.

Nancy Guthrie’s home is considered a crime scene, Nanos said.

DNA samples collected from her home have been confirmed to belong to her, though authorities have not yet confirmed if they were blood, the sheriff’s department said Tuesday. There has been nothing to indicate any suspects from the samples taken from the home so far, Nanos said.

It is unknown if Nancy Guthrie was targeted or if this was random, Nanos said.

“We don’t know,” he said. “We’re going to assume both sides of that.”

Nanos said Tuesday investigators were waiting to get surveillance footage from the home’s security cameras from the companies that own them.

“We’ve asked them. They know the urgency here,” Nanos said.

Investigators are also looking into a camera that was missing from the front of the house, he said.

Authorities said they have Nancy Guthrie’s cell phone. Sources briefed on the probe told ABC News that investigators are focusing on Nancy Guthrie’s electronic devices to see if there is data that could point to an assailant or a specific time when the abduction would have occurred.

Investigators who processed her home on Sunday “saw some things at the home that were concerning to us,” Nanos previously said.

Investigators are also paying attention to the condition of the home and whether things were moved or left out of place, which could suggest that someone with greater strength or agility was in the home and when, sources said.

The FBI urged people to submit tips.

“We are looking at this from every angle, but we need your help,” Jon Edwards, assistant special agent in charge of the FBI’s office in Tucson, said during Tuesday’s briefing. “Every lead and tip is important. We are aggressively pursuing and looking into every single one.”

“Please help us bring Nancy Guthrie home,” he added.

Nancy Guthrie is described as having some physical ailments and limited mobility, but does not have cognitive issues, according to the sheriff. She takes medication that if she doesn’t have in 24 hours, “it could be fatal,” Nanos said.

In an Instagram post on Monday night, Savannah Guthrie asked her followers for prayers amid the investigation.

“Thank you for lifting your prayers with ours for our beloved mom, our dearest Nancy, a woman of deep conviction, a good and faithful servant. raise your prayers with us and believe with us that she will be lifted by them in this very moment,” the talk show host wrote.

President Donald Trump said on Tuesday that the situation is “terrible” and said he would call Savannah Guthrie.

Anyone with information is urged to call 911 or the Pima County Sheriff’s Department at 520-351-4900.

ABC News’ Trevor Ault, Josh Margolin and Luke Barr contributed to this report.