The Duke Blue Devils will face off against the St. John’s Red Storm in the Sweet 16 of the NCAA tournament. Duke is fresh off an 81-58 win over TCU, while St. John’s won 67-65 against Kansas in the second round.

With that in mind, let’s look at the predictions, odds and picks for the March 27 showdown.

Duke vs. St. John’s Sweet 16 predictions, odds & picks for March 27

Asbury Park Press’ Jerry Carino has St. John’s picking up the win by a 63-61 score in today’s game. Carino believes the Red Storm’s experience and superior head coach should be enough to pull off an upset win.

Here’s the odds for the showdown:

• Moneyline: Duke (-258), St. John’s (+210)
• Spread: Duke (-6.5)
• Total: 141.5

Duke hasn’t been as dominant as expected so far in March Madness. The Blue Devils survived a scare against the Siena Saints in the Round of 64 and suffered early struggles against the TCU Horned Frogs before pulling away in the second round.

Duke will rely on the standout freshman forward Cameron Boozer. Boozer put up 22 points against Siena and 19 against TCU, and he’s tipped as a Top 3 pick in the 2026 NBA draft. Recently injured stars, point guard Caleb Foster and center Patrick Ngongba II, are in line to feature against St. John’s.

St. John’s is one of the in-form teams in the nation. They’ve lost just once in their last ten games and looked solid in their March Madness games against Northern Iowa and Kansas.

Rick Pitino is one of college basketball’s most accomplished coaches, and he’s getting great value from his experienced team entering the Duke showdown. It’ll be interesting to see how he sets up his team to limit Cameron Boozer and his supporting cast’s efficiency.

The Blue Devils and Red Storm are two well-coached teams with unique approaches to the game. They’ll look to attack the paint, exploit mismatches and remain defensively sound for the duration of the contest.

Duke vs. St. John’s Sweet 16: How to watch?

Here’s how to watch the showdown:

• Date: Friday, March 27, 2026
• Time: 7:10 p.m. ET
• Venue: Capital One Arena in Washington, D.C.
• Livestream: FuboTV and DAZN
• TV Channel: CBS