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Mariners vs. Guardians preview: Odds, Predictions, Betting Tips & Starting lineups | March 26; MLB 2026 Season


The Seattle Mariners begin their 2026 MLB season on Thursday, hosting the Cleveland Guardians at T-Mobile Park.

Both teams enjoyed success in 2025. The Mariners won their division, the AL West, for the first time since 2001, making it all the way to the ALCS. The Guardians, on the other hand, won the AL Central for the second consecutive year.

Let’s take a look at the odds, preview, prediction and best betting tips for this fixture.

MLB: Seattle Mariners vs Cleveland Guardians Odds

Money Line: Seattle Mariners (-184), Cleveland Guardians (+159)

Run Line: Seattle Mariners -1.5 (+123), Cleveland Guardians +1.5 (-149)

Total Runs: Over 7 (+104), Under 7 (-125)

Preview – Probable starting pitchers and lineups

Seattle Mariners probable starting pitcher: Logan Gilbert

Logan Gilbert gets the nod to start the MLB season opener for the hosts. Since making his debut in 2021, Gilbert has established himself as one of the best in the big leagues. He enjoyed a solid 2025 season, finishing with a 6-6 record, 3.44 ERA and 173 strikeouts.

Logan Gilbert in action for the Seattle Mariners - Source: Getty
Logan Gilbert in action for the Seattle Mariners – Source: Getty

Seattle Mariners predicted lineup:

  1. 3B Brendan Donovan
  2. C Cal Raleigh
  3. OF Julio Rodriguez
  4. 1B Josh Naylor
  5. OF Randy Arozarena
  6. OF Luke Raley
  7. DH Dominic Canzone
  8. 2B Cole Young
  9. SS Leo Rivas

Cleveland Guardians probable starting pitcher: Tanner Bibee

Tanner Bibee takes the mound for the visitors. Having made his MLB debut in 2023, the righty has gone on to make a name for himself as arguably the Guardians’ most reliable starter. He finished the 2025 season with a 12-11 record, 4.25 ERA and 162 strikeouts.

Tanner Bibee in action for the Cleveland Guardians - Source: Getty
Tanner Bibee in action for the Cleveland Guardians – Source: Getty

Cleveland Guardians predicted lineup:

  1. OF Steven Kwan
  2. OF Chase DeLauter
  3. 3B Jose Ramirez
  4. 1B Kyle Manzardo
  5. DH Rhys Hoskins
  6. OF Angel Martinez
  7. C Bo Naylor
  8. SS Gabriel Arias
  9. 2B Brayan Rocchio

The Guardians boast plenty of quality in their ranks, but the Mariners are a force to be reckoned with at T-Mobile Park, and should have enough in the tank to begin their MLB regular season journey with a win.

Prediction: Seattle Mariners 3, Cleveland Guardians 2

Betting Tips

With Gilbert and Bibee on the mound, this has all the makings of a rather low-scoring fixture. The Seattle Mariners should be able to make the most of their home-field advantage to secure a hard-fought win.

Money Line: Seattle Mariners (-184)

Run Line: Cleveland Guardians +1.5 (-149)

Total Runs: Under 7 (-125)

Likely players to hit home runs: Cal Raleigh (Seattle Mariners), Josh Naylor (Seattle Mariners), Jose Ramirez (Cleveland Guardians), Rhys Hoskins (Cleveland Guardians)